Dr Sepanta Hosseinpour
Clinical Senior Lecturer - Endodontics
School of Dentistry
Researcher biography
Dr Sepanta Hosseinpour is a Clinical Senior Lecturer and Chief Examiner at the School of Dentistry, The University of Queensland, and a Fellow of the UK Higher Education Academy (FHEA). He is a specialist endodontist and an Examiner for the Royal Australasian College of Dental Surgeons (RACDS) Primary Examinations.
Sepanta obtained his Doctor of Dental Surgery (DDS) and Master of Public Health (MPH) in 2017. He completed his PhD at The University of Queensland in 2023, where his research in regenerative dentistry and tissue regeneration was recognised with the Dean's Award for Outstanding Higher Degree by Research Thesis. He completed three years of accredited specialist training and was awarded the Doctor of Clinical Dentistry (DClinDent) in Endodontics.
Dr Hosseinpour has authored and edited a book on regenerative dentistry and has published over 60 peer-reviewed journal articles and book chapters. He is an active researcher and educator with interests spanning endodontics, regenerative dentistry, biomaterials, and dental education, and regularly delivers invited lectures and presentations at national and international meetings.
Book Chapters
Hosseinpour, Sepanta, Nanda, Ashwin, Lei, Chang, Lowe, Baboucarr, Ye, Qingsong and Xu, Chun (2021). Nanobiomaterials in craniofacial bone regeneration. Advances in Dental Implantology using Nanomaterials and Allied Technology Applications. (pp. 25-52) edited by Ramesh S. Chaughule and Rajesh Dashaputra. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-52207-0_2
Rezai Rad, Maryam, Hosseinpour, Sepanta, Ye, Qingsong and Yao, Shaomian (2021). Dental tissues originated stem cells for tissue regeneration. Regenerative approaches in dentistry: an evidence-based perspective. (pp. 9-33) edited by Sepanta Hosseinpour, Laurence J. Walsh and Keyvan Moharamzadeh. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-030-59809-9_2
Walsh, Laurence J. and Hosseinpour, Sepanta (2021). The paradigm of regenerative dentistry and its future perspectives. Regenerative Approaches in Dentistry. (pp. 1-8) edited by Sepanta Hosseinpour, Laurence J. Walsh and Keyvan Moharamzadeh. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-030-59809-9_1
Khojasteh, Arash and Hosseinpour, Sepanta (2020). Challenges in the rehabilitation handling of large and localized oral and maxillofacial defects. Applications of biomedical engineering in dentistry. (pp. 239-262) edited by Lobat Tayebi. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-21583-5_11
Journal Articles
Sun, Ruiyi, Amidi, Sarina, Yee, Jia Ying, Liaw, Andrew, Hosseinpour, Sepanta, Ivanovski, Sašo, Kocak Oztug, Necla Asli and Han, Pingping (2025). A survey of Australian consumers' and dentists’ perceptions of saliva as a biofluid for periodontitis diagnosis. BMC Oral Health, 25 (1) 1672, 1672. doi: 10.1186/s12903-025-07062-3
Ye, Yicheng, Hosseinpour, Sepanta, Wen, Juan and Peters, Ove A. (2025). In Vitro Bioactivity and Cytotoxicity Assessment of Two Root Canal Sealers. Materials, 18 (15) 3717, 3717-15. doi: 10.3390/ma18153717
Huang, Raewyn, Chen, Wei, Fang, Matthew, Peters, Ove A. and Hosseinpour, Sepanta (2025). Clinical and radiographic outcomes of autologous platelet-rich products in regenerative endodontics: a systematic review and meta-analysis. Dentistry Journal, 13 (6) 236, 236-6. doi: 10.3390/dj13060236
Chien, Philip Y.‐H., Hosseinpour, Sepanta, Peters, Ove A. and Peters, Christine I. (2025). Outcomes of root canal treatment performed by undergraduate students: A systematic review and meta‐analysis. International Endodontic Journal. doi: 10.1111/iej.14246
Liu, Jingyu, Hosseinpour, Sepanta, Xu, Chun, Wang, Tony and Yan, Cheng (2025). Bioinspired hierarchical porous tricalcium phosphate scaffold prepared via freeze casting combined with material jetting templating. Journal of Materials Engineering and Performance, 34 (21), 25265-25272. doi: 10.1007/s11665-025-11774-6
Ghafari, Mahan, Hosseinpour, Sepanta, Rezaee-Zavareh, Mohammad Saeid, Dascalu, Stefan, Rostamian, Somayeh, Aramesh, Kiarash, Madani, Kaveh and Kordasti, Shahram (2023). A quantitative evaluation of the impact of vaccine roll-out rate and coverage on reducing deaths: insights from the first 2 years of COVID-19 epidemic in Iran. BMC Medicine, 21 (1) 429, 1-9. doi: 10.1186/s12916-023-03127-8
Hosseinpour, Sepanta, Dai, Huan, Walsh, Laurence J. and Xu, Chun (2023). Mesoporous core–cone silica nanoparticles can deliver miRNA-26a to macrophages to exert immunomodulatory effects on osteogenesis in vitro. Nanomaterials, 13 (11) 1755, 1755. doi: 10.3390/nano13111755
Shieh, Karissa, Yang, Jack, Zhu, Elsa Heng, Peters, Ove Andreas and Hosseinpour, Sepanta (2023). Dentinal tubule penetrability and bond strength of two novel calcium silicate-based root canal sealers. Materials, 16 (9) 3309, 3309. doi: 10.3390/ma16093309
Guo, Jindong, Peters, Ove A. and Hosseinpour, Sepanta (2023). Immunomodulatory effects of endodontic sealers: a systematic review. Dentistry Journal, 11 (2) 54, 54. doi: 10.3390/dj11020054
Hosseinpour, Sepanta, Gomez-Cerezo, Maria Natividad, Cao, Yuxue, Lei, Chang, Dai, Huan, Walsh, Laurence J., Ivanovski, Saso and Xu, Chun (2022). A comparative study of mesoporous silica and mesoporous bioactive glass nanoparticles as non-viral microRNA vectors for osteogenesis. Pharmaceutics, 14 (11) 2302, 1-19. doi: 10.3390/pharmaceutics14112302
Xu, Chun, Lei, Chang, Hosseinpour, Sepanta, Ivanovski, Saso, Walsh, Laurence J. and Khademhosseini, Ali (2022). Nanotechnology for the management of COVID-19 during the pandemic and in the post-pandemic era. National Science Review, 9 (10) nwac124, 1-13. doi: 10.1093/nsr/nwac124
Qi Lim, Ping, Huey Lim, Sue, Sherilyn, Maria, Fernandez-Medina, Tulio, Ivanovski, Sašo and Hosseinpour, Sepanta (2022). A clinical risk assessment of a 3D-printed patient-specific scaffold by failure modes and effects analysis. Materials, 15 (15) 5442, 1-11. doi: 10.3390/ma15155442
Dai, Huan, Hosseinpour, Sepanta, Hua, Shu and Xu, Chun (2022). Advances in porous inorganic nanomaterials for bone regeneration. Nano TransMed, 1 (1) 9130005, 1-12. doi: 10.26599/ntm.2022.9130005
Hosseinpour, S., Gaudin, A. and Peters, O. A. (2022). A critical analysis of research methods and experimental models to study biocompatibility of endodontic materials. International Endodontic Journal, 55 (S2), 346-369. doi: 10.1111/iej.13701
Aubeux, Davy, Peters, Ove A., Hosseinpour, Sepanta, Tessier, Solène, Geoffroy, Valérie, Pérez, Fabienne and Gaudin, Alexis (2021). Specialized pro-resolving lipid mediators in endodontics: a narrative review. BMC Oral Health, 21 (1) 276, 276. doi: 10.1186/s12903-021-01619-8
Hosseinpour, Sepanta, Walsh, Laurence J. and Xu, Chun (2021). Modulating osteoimmune responses by mesoporous silica nanoparticles. ACS Biomaterials Science and Engineering, 8 (10) acsbiomaterials.1c00899, 4110-4122. doi: 10.1021/acsbiomaterials.1c00899
Hosseinpour, Sepanta, Nanda, Ashwin, Walsh, Laurence J. and Xu, Chun (2021). Microbial decontamination and antibacterial activity of nanostructured titanium dental implants: a narrative review. Nanomaterials, 11 (9) 2336, 2336. doi: 10.3390/nano11092336
Shekarchi, Fatemeh, Rezai Rad, Maryam, MalekAfzali, Beheshteh, Hosseinpour, Sepanta and Khojasteh, Arash (2021). Modulated cementogenic genes upregulation in human buccal fat pad-derived stem cells by strontium-ranelate. Gene Reports, 23 101056, 101056. doi: 10.1016/j.genrep.2021.101056
Hosseinpour, Sepanta, Cao, Yuxue, Liu, Jingyu, Xu, Chun and Walsh, Laurence J. (2021). Efficient transfection and long-term stability of rno-miRNA-26a-5p for osteogenic differentiation by large pore sized mesoporous silica nanoparticles. Journal of Materials Chemistry B, 9 (9), 2275-2284. doi: 10.1039/d0tb02756a
Lei, Chang, Cao, Yuxue, Hosseinpour, Sepanta, Gao, Fang, Liu, Jingyu, Fu, Jianye, Staples, Reuben, Ivanovski, Saso and Xu, Chun (2021). Hierarchical dual-porous hydroxyapatite doped dendritic mesoporous silica nanoparticles based scaffolds promote osteogenesis in vitro and in vivo. Nano Research, 14 (3), 770-777. doi: 10.1007/s12274-020-3112-2
Hosseinpour, Sepanta, Xu, Chun and Walsh, Laurence J. (2021). Impact of photobiomodulation using four diode laser wavelengths of on cationic liposome gene transfection into pre-osteoblast cells. Journal of Photochemistry and Photobiology B: Biology, 215 112108, 112108. doi: 10.1016/j.jphotobiol.2020.112108
Hosseinpour, Sepanta and Wals, Laurence (2021). Laser‐assisted nucleic acid delivery: a systematic review. Journal of Biophotonics, 14 (1) e202000295, e202000295. doi: 10.1002/jbio.202000295
Hosseinpour, Sepanta, Walsh, Laurence J. and Xu, Chun (2020). Biomedical application of mesoporous silica nanoparticles as delivery system: a biological-safety perspective. Journal of Materials Chemistry B, 8 (43), 9863-9876. doi: 10.1039/d0tb01868f
Hosseinpour, Sepanta, Tuner, Jan and Fekrazad, Reza (2019). Photobiomodulation in oral surgery: a review. Photobiomodulation Photomedicine and Laser Surgery, 37 (12), 814-825. doi: 10.1089/photob.2019.4712
Tuner, Jan, Hosseinpour, Sepanta and Fekrazad, Reza (2019). Photobiomodulation in temporomandibular disorders. Photobiomodulation Photomedicine and Laser Surgery, 37 (12) photob.2019.4705, 826-836. doi: 10.1089/photob.2019.4705
Hosseinpour, Sepanta, Fekrazad, Reza, Arany, Praveen R. and Ye, Qingsong (2019). Molecular impacts of photobiomodulation on bone regeneration: a systematic review. Progress in Biophysics and Molecular Biology, 149, 147-159. doi: 10.1016/j.pbiomolbio.2019.04.005
Hosseinpour, Sepanta, He, Yan, Nanda, Ashwin and Ye, Qingsong (2019). MicroRNAs involved in the regulation of angiogenesis in bone regeneration. Calcified Tissue International, 105 (3), 223-238. doi: 10.1007/s00223-019-00571-8
Khojasteh, Arash, Hosseinpour, Sepanta, Rezai Rad, Maryam, Alikhasi, Marzieh and Zadeh, Homayoun H. (2019). Buccal fat pad-derived stem cells with anorganic bovine bone mineral scaffold for augmentation of atrophic posterior mandible: an exploratory prospective clinical study. Clinical Implant Dentistry and Related Research, 21 (2), 292-300. doi: 10.1111/cid.12729
Salehi, Majid, Ehtrami, Arian, Bastami, Farshid, Farzamfar, Saeed, Hosseinpour, Sepanta, Vahedi, Hamid, Vaez, Ahmad, Rahvar, Mostafa and Goodarzi, Arash (2019). Polyurethane/gelatin nanofiber neural guidance conduit in combination with resveratrol and Schwann cells for sciatic nerve regeneration in the rat model. Fibers and Polymers, 20 (3), 490-500. doi: 10.1007/s12221-019-8939-3
Khojasteh, Arash, Hosseinpour, Sepanta, Rezai Rad, Maryam and Alikhasi, Marzieh (2019). Buccal fat pad-derived stem cells in three-dimensional rehabilitation of large alveolar defects: a report of two cases. Journal of Oral Implantology, 45 (1), 45-54. doi: 10.1563/aaid-joi-D-17-00215
Vahabi, Surena, Nazemisalman, Bahareh, Kalantari, Mahsa and Hosseinpour, Sepanta (2019). Association of matrix metalloproteinase-1-1607 1g/2g and C-reactive protein-717 C/T gene polymorphisms in Iranian patients with chronic periodontitis: a clinical trial. Iranian Red Crescent Medical Journal, 21 (1). doi: 10.5812/ircmj.84396
Nazemisalman, Bahareh, Vahabi, Surena, Sabouri, Ehsan, Hosseinpour, Sepanta and Doaju, Sara (2018). Association of vitamin D binding protein and vitamin D receptor gene polymorphisms in Iranian patients with chronic periodontitis. Odontology, 107 (1), 46-53. doi: 10.1007/s10266-018-0383-0
Vahabi, Surena, Nazemisalman, Bahareh, Hosseinpour, Sepanta, Salavitabar, Simindokht and Aziz, Alireza (2018). Interleukin-2, -16, and -17 gene polymorphisms in Iranian patients with chronic periodontitis. Journal of Investigative and Clinical Dentistry, 9 (2), e12319. doi: 10.1111/jicd.12319
Hosseinpour, Sepanta, Rad, Maryam Rezai, Khojasteh, Arash and Zadeh, Homayoun H (2018). Antibody administration for bone tissue engineering: a systematic review. Current stem cell research and therapy, 13 (4), 292-315. doi: 10.2174/1574888X13666180207095314
Shahrezaee, Mostafa, Oryan, Ahmad, Bastami, Farshid, Hosseinpour, Sepanta, Shahrezaee, Mohammad Hossein and Kamali, Amir (2018). Comparative impact of systemic delivery of atorvastatin, simvastatin, and lovastatin on bone mineral density of the ovariectomized rats. Endocrine, 60 (1), 138-150. doi: 10.1007/s12020-018-1531-6
Khojasteh, A., Hosseinpour, S., Dehghan, M. M., Mashhadiabbas, F., Rezai Rad, M., Ansari, S., Farzad Mohajeri, S. and Zadeh, H. H. (2018). Antibody-mediated osseous regeneration for bone tissue engineering in canine segmental defects. BioMed Research International, 2018 9508721, 1-10. doi: 10.1155/2018/9508721
Dalaie, Kazem, Behnaz, Mohammad, Khodabakhshi, Zahra and Hosseinpour, Sepanta (2018). Impact of malocclusion severity on oral health-related quality of life in an Iranian young adult population. European Journal of Dentistry, 12 (1), 129-135. doi: 10.4103/ejd.ejd_61_17
Kadkhodazadeh, Mahdi, Amid, Reza, Kermani, Mehdi Ekhlasmand and Hosseinpour, Sepanta (2018). A modified frenectomy technique: a new surgical approach. General dentistry, 66 (1), 34-38.
Behnaz, Mohammad, Dalaie, Kazem, Hosseinpour, Sepanta, Namvar, Fatemeh and Kazemi, Leila (2017). The effect of toothpastes with bleaching agents on the force decay of elastomeric orthodontic chains. European Journal of Dentistry, 11 (4), 427-431. doi: 10.4103/ejd.ejd_83_17
Tabrizi, Reza, Nazhvanai, Ali Dehghani, Farahmand, Mohammad Mahdi, Pourali, Sara Yasour and Hosseinpour, Sepanta (2017). Do increased drilling speed and depth affect bone viability at implant site?. Dental Research Journal, 14 (5), 331-335. doi: 10.4103/1735-3327.215963
Tabari, Kasra, Hosseinpour, Sepanta and Mohammad-Rahimi, Hossein (2017). The impact of plasma treatment of cercon (R) zirconia ceramics on adhesion to resin composite cements and surface properties. Journal of Lasers in Medical Sciences, 8 (3), S56-S61. doi: 10.15171/jlms.2017.s11
Hosseinpour, Sepanta, Ahsaie, Mitra Ghazizadeh, Rad, Maryam Rezai, Baghani, Mohammad Taghi, Motamedian, Saeed Reza and Khojasteh, Arash (2017). Application of selected scaffolds for bone tissue engineering: a systematic review. Oral and Maxillofacial Surgery, 21 (2), 109-129. doi: 10.1007/s10006-017-0608-3
Kadkhodazadeh, Mahdi, Amid, Reza, Kermani, Mehdi Ekhlasmand, Mirakhori, Mahdieh and Hosseinpour, Sepanta (2017). Timing of soft tissue management around dental implants: a suggested protocol. General Dentistry, 65 (3), 50-56.
Hosseinpour, Sepanta and Bastami, Farshid (2017). Critical-sized bone defects in mandible of canine model. Tissue Engineering Part a, 23 (9-10), 470-470. doi: 10.1089/ten.tea.2016.0241
Ghorbanzadeh, Sajedeh, Ashraf, Hengameh, Hosseinpour, Sepanta and Ghorbanzadeh, Fatemeh (2017). Nonsurgical management of a large periapical lesion: a case report. Iranian Endodontic Journal, 12 (2), 253-256. doi: 10.22037/iej.2017.49
Hosseinpour, Sepanta, Mashhadiabbas, Fatemeh and Ahsaie, Mitra Ghazizadeh (2017). Diagnostic biomarkers in oral verrucous carcinoma: a systematic review. Pathology and Oncology Research, 23 (1), 19-32. doi: 10.1007/s12253-016-0150-x
Tabari, Kasra, Hosseinpour, Sepanta, Parashos, Peter, Kardouni Khozestani, Parisa and Rahimi, Hossein Mohammad (2017). Cytotoxicity of selected nanoparticles on human dental pulp stem cells. Iranian Endodontic Journal, 12 (2), 137-142. doi: 10.22037/iej.2017.28
Bagrizan, Majid, Pourgolshani, Pouya, Hosseinpour, Sepanta, Jalalpour, Golnoush and Shahrestani, Mostafa Zahmatkesh (2017). Plasma level formaldehyde in children receiving pulpotomy treatment under general anesthesia. Journal of Clinical Pediatric Dentistry, 41 (2), 95-101. doi: 10.17796/1053-4628-41.2.95
Safi, Yaser, Ghaedsharaf, Sahar, Aziz, Alireza, Hosseinpour, Sepanta and Mortazavi, Hamed (2017). Effect of Field Of View on Detection of External Root Resorption in Cone-Beam Computed Tomography. Iranian Endodontic Journal, 12 (2), 179-184. doi: 10.22037/iej.2017.35
Naseri, Mandana, Kharazifard, Mohammad Javad and Hosseinpour, Sepanta (2016). Canal configuration of mesiobuccal roots in permanent maxillary first molars in Iranian population: a systematic review. Journal of Dentistry, 13 (6), 438-447.
Khojasteh, A., Hosseinpour, S., Nazeman, P. and Dehghan, M. M. (2016). The effect of a platelet-rich fibrin conduit on neurosensory recovery following inferior alveolar nerve lateralization: a preliminary clinical study. International Journal of Oral and Maxillofacial Surgery, 45 (10), 1303-1308. doi: 10.1016/j.ijom.2016.06.003
Tabrizi, Reza, Hosseinpour, Sepanta and Taghizadeh, Fateme (2016). Feeding in oral cancer patients after massive ablative surgery: percutaneous endoscopic gastrostomy or nasogastric tube. Journal of Craniofacial Surgery, 27 (4), 1010-1011. doi: 10.1097/SCS.0000000000002662
Hosseinpour, Sepanta, Kharazifard, Mohammad Javad, Khayat, Akbar and Naseri, Mandana (2016). Root canal morphology of permanent mandibular premolars in Iranian population: a systematic review. Iranian Endodontic Journal, 11 (3), 150-6. doi: 10.7508/iej.2016.03.001
Safi, Yaser, Hosseinpour, Sepanta, Aziz, Alireza, Bamedi, Masoud, Malekashtari, Mahsa and Vasegh, Zahra (2016). Effect of amperage and field of view on detection of vertical root fracture in teeth with intracanal posts. Iranian Endodontic Journal, 11 (3), 202-7. doi: 10.7508/iej.2016.03.011
Motamedian, Saeed Reza, Hosseinpour, Sepanta, Ahsaie, Mitra Ghazizadeh and Khojasteh, Arash (2015). Smart scaffolds in bone tissue engineering: a systematic review of literature. World Journal of Stem Cells, 7 (3), 657-68. doi: 10.4252/wjsc.v7.i3.657
Thesis
Hosseinpour Dougolsar, Sepanta (2023). Mesoporous silica nanoparticle-based non-viral gene delivery systems for bone regeneration. PhD Thesis, School of Dentistry, The University of Queensland. doi: 10.14264/086453e