Group for Anodized Therapies for Osseointegration, Regeneration and Stimulation (GATORs)
Vision
Our vision is to revolutionize dental implant technology by creating the next generation of implants capable of providing maximum local therapeutic action with selective bioactivity to drastically reduce implant failures.
Research focus
Our research focusses on nano-engineering of dental implants to enable local drug release and enhanced bioactivity, targeting dental implant failure, especially associated with ongoing conditions (osteoporosis, diabetes, aged patients and smokers). Electrochemical anodization is used to impart controlled nanotopography to conventional dental implants to augment osseo- and soft-tissue integration, and achieve immunomodulation and antibacterial functions, via tailored local therapies. The technology translates well into all metal implants (Ti, Zr, alloys, etc.) and orthopaedic implants.
Dr Gulati’s GATORs group aligns well with the vision of COR3 group: novel dental solutions towards regeneration, reconstruction and rehabilitation. The technologies and strategies employed in GATORs group are cost-effective and scalable, ensuring clinical translation.
Research grants
- ITI-International Team for Implantology Research Grant (2021)
- NHMRC Early Career Fellowship (2018-21)
- Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship (2021-22)
- Erasmus+ Scholarships for Staff Mobility for Teaching (Germany) (2021-22)
- Australian Dental Research Foundation (ADRF) Research Grants (2021-22)
- Australian Periodontology Research Foundation (APRF) Research Grant (2021)
- ITI-International Team for Implantology Research Grant (2019)
News and media engagement
Cover Story: New research by Dr Karan Gulati may lead to a solution to the problem of implant failure. September 2020.
Advanced nanotechnology used to improve success of dental implants (2020)
UQ HABS Media Inclusion (2020): UQ’s advanced nanotechnology to improve success of dental implants.
UQ HABS Research Week inclusion
Media Engagement. Griffith University. Nano-engineered dental implants set to reduce costs and infection risks.
Media Engagement. Channel 9 News Gold Coast. The costly complications of dental implants could soon be a thing of the past. Gold Coast researchers are pioneering a ground-breaking solution to stop infections taking hold.
Recent outputs (since 2021)
Books
- Book ‘Surface Modification of Titanium Dental Implants’ in Springer Nature Switzerland AG. 2023. ed. by K. Gulati. https://link.springer.com/book/10.1007/978-3-031-21565-0
https://doi.org/10.1007/978-3-031-21565-0
- K. Gulati. Nano-Engineering Solutions for Dental Implant Applications. MDPI 2022. ISBN 978-3-0365-3144-1 (Hbk); ISBN 978-3-0365-3145-8 (PDF). This book is a printed edition of the Special Issue Nano-Engineering Solutions for Dental Implant Applications that was published in Nanomaterials
https://www.mdpi.com/books/pdfview/book/5006
https://doi.org/10.3390/books978-3-0365-3145-8
- S. Ivanovski, K. Gulati and A. Abdal-hay. Novel Nano-Engineered Biomaterials for Bone Tissue Engineering. ISBN 978-3-0365-3349-0 (Hbk); ISBN 978-3-0365-3350-6 (PDF). This book is a printed edition of the Special Issue Novel Nano-Engineered Biomaterials for Bone Tissue Engineering that was published in Nanomaterials
https://doi.org/10.3390/books978-3-0365-3350-6
Book chapters
- Guo, T., Ivanovski, S., Gulati, K. (2023). From Micro to Nano: Surface Modification for Enhanced Bioactivity of Titanium Dental Implants. In: Gulati, K. (eds) Surface Modification of Titanium Dental Implants. Springer, Cham. https://doi.org/10.1007/978-3-031-21565-0_5
- Jayasree, A., Ivanovski, S., Gulati, K. (2023). Local Therapy from Nano-engineered Titanium Dental Implants. In: Gulati, K. (eds) Surface Modification of Titanium Dental Implants. Springer, Cham. https://doi.org/10.1007/978-3-031-21565-0_6
- Chopra, D., Gulati, K. (2023). Mechanical Stability of Anodized Nano-engineered Titanium Dental Implants. In: Gulati, K. (eds) Surface Modification of Titanium Dental Implants. Springer, Cham. https://doi.org/10.1007/978-3-031-21565-0_7
- Guo, T., Scimeca, JC., Ivanovski, S., Verron, E., Gulati, K. (2023). Cytotoxicity, Corrosion and Electrochemical Stability of Titanium Dental Implants. In: Gulati, K. (eds) Surface Modification of Titanium Dental Implants. Springer, Cham. https://doi.org/10.1007/978-3-031-21565-0_8
- K. Gulati. ‘Electrochemically Nano-Engineered Titanium Implants towards Local Drug Delivery Applications’ in book Advanced Porous Biomaterials for Drug Delivery Applications. 2022, ed. by M. Kurkuri, D. Losic, Uthappa, Ho-Young-Jung. CRC Press (Taylor & Francis Group). https://www.routledge.com/Advanced-Porous-Biomaterials-for-Drug-Delivery-Applications/Kurkuri-Losic-Uthappa-Jung/p/book/9781032107981
- K. Gulati. ‘Supramolecular Surface Modifications of Titanium Implants’ in book Supramolecular Chemistry in Corrosion and Biofouling Protection. 2021, ed. by V.S. Saji. CRC Press (Taylor & Francis Group). https://doi.org/10.1201/9781003169130-28
Journal publications (since 2021)
2025 (4)
- D. Chopra, L. Zhang, T. Guo, S. Ivanovski, R. Qiao* and K. Gulati*. Nanoparticles Decorated Nanotubes: Advanced Local Therapies from Anodized Nano-Engineered Titanium Implants. Advanced Functional Materials [Senior/Last Authorship, *Corresponding Author, IF 19]. Accepted 16 June 2025
- V.T. Ngo, K. Gulati*, C.S. Law, N.Q.H. Tran, J. Lin, D.L. Stachura, A.D. Abell, H. Zhang*, A. Santos*. Titania Nanopores as Photoelectrocatalysts for Coupling Hydrogen Production with Plastic Reformation. Advanced Science 2025, e09287 [*Corresponding Author, IF 14.1]. https://doi.org/10.1002/advs.202509287
- G. Shineh, L. M. Janghour, Y. Xia, J. Shao, K. Gulati, G. Yeo, B. Akhavan. Biomolecule-functionalized dental implant surfaces: Towards augmenting soft tissue integration. Bioactive Materials 2025, 53, 540-590. [IF 20.3]. https://doi.org/10.1016/j.bioactmat.2025.07.005
- X. Dong, H. Liu, D. Yuan, K. Gulati*, Y. Liu*. Re-Engineering Bone: Pathogenesis, Diagnosis and Emerging Therapies for Osteoporosis. Journal of Materials Chemistry B 2025, 13, 4938-4963 [*Corresponding Author, IF 5.7]. https://doi.org/10.1039/D4TB02628D Emerging Investigators Themed Collection.
2024 (3)
- H. Moon#, K. Gulati#*, T. Li, C.S. Moran and S. Ivanovski*. Inflammatory or Reparative? Tuning Macrophage Polarization using Anodized Anisotropic Nanoporous Titanium Implant Surfaces. Small Science 2024, 4, 2400211 [#Shared First-Authorship, *Corresponding Author, IF 8.3]. https://doi.org/10.1002/smsc.202400211
- D. Chopra, T. Guo, A. Jayasree, K. Gulati* and S. Ivanovski*. Bioinspired, Bioactive and Bactericidal: Anodized Nanotextured Dental Implants. Advanced Functional Materials 2024, 34, 2314031. [*Corresponding Author, IF 19]. https://doi.org/10.1002/adfm.202314031
- A. Jayasree, S. Cartmell, S. Ivanovski and K. Gulati*. Electrically Stimulated Dental Implants Triggers Soft-Tissue Integration and Bactericidal Functions. Advanced Functional Materials 2024, 34, 2311027. [*Corresponding Author, IF 19]. https://doi.org/10.1002/adfm.202311027
2023 (7)
- A. Jayasree, C. Liu, C. Salomon, S. Ivanovski*, K. Gulati* and P. Han*. Microvesicle-Eluting Nano-Engineered Implants Influence Inflammatory Response of Keratinocytes. Drug Delivery and Translational Research 2023 [*Corresponding Author, IF 5.5]. Accepted 17 Oct 2023. https://doi.org/10.1007/s13346-023-01457-x
- D. Chopra, T. Guo, K. Gulati* and S. Ivanovski*. Load, Unload and Repeat: Understanding the Mechanical Characteristics of Zirconia in Dentistry. Dental Materials 2024, 40, e1-e17 [*Corresponding Author, IF 6.3]. https://doi.org/10.1016/j.dental.2023.10.007 Featured as the most downloaded articles in the last 90 days (March 2024).
- K. Gulati* and T. Adachi. Profiling to Probing: Atomic Force Microscopy to Characterize Nano-Engineered Implants. Acta Biomaterialia 2023, 170, 15-38 [*Corresponding Author, IF 9.6]. https://doi.org/10.1016/j.actbio.2023.08.006
- K. Gulati*, D. Chopra, N.A. Kocak-Oztug and E. Verron. Fit and Forget: The Future of Dental Implant Therapy Via Nanotechnology. Advanced Drug Delivery Reviews 2023, 199, 114900. [*Corresponding Author, IF 17.6]. https://doi.org/10.1016/j.addr.2023.114900 Invited Article for the Special Issue ‘Emerging Voices in Drug Delivery’.
- D. Chopra, A. Jayasree, T. Guo, K. Gulati* and S. Ivanovski*. Random, Aligned and Grassy: Bioactivity and Biofilm Analysis of Zirconia Nanostructures as Dental Implant Modification. Composites Part B: Engineering 2023, 259, 110725. [*Corresponding Author, IF 14.2]. https://doi.org/10.1016/j.compositesb.2023.110725
- K. Gulati#, C. Ding#, T. Guo, H. Guo, H. Yu* and Y. Liu*. Craniofacial Therapy: Advanced Local Therapies from Nano-Engineered Titanium Implants to Treat Craniofacial Conditions. [#Shared First-Authorship, IF 12.2]. International Journal of Oral Science 2023, 15, 15. https://doi.org/10.1038/s41368-023-00220-9
- T. Guo, J-C. Scimeca, S. Ivanovski*, E. Verron* and K. Gulati*. Enhanced Corrosion Resistance and Local Therapy from Nano-Engineered Titanium Dental Implants. Pharmaceutics 2023, 15(2), 315 [Senior/Last Authorship, *Corresponding Author, IF 5.5]. https://doi.org/10.3390/pharmaceutics15020315
2022 (12)
- M. Bayrak, N.A. Kocak-Oztuğ, K. Gulati, S. Cintan, and E. Cifcibasi. Influence of Clinical Decontamination Techniques on the Surface Characteristics of SLA Titanium Implant. Nanomaterials 2022, 12(24), 4481. [IF 4.3]. https://doi.org/10.3390/nano12244481
- P. Han*, T. Guo, A. Jayasree, G.A. Gomez, K. Gulati*, and S. Ivanovski*. Tunable Nano-engineered Anisotropic Surface for Enhanced Mechanotransduction and Soft-Tissue Integration. Nano Research 2023, 16, 7293–7303. [*Corresponding Author, IF 9.0]. https://doi.org/10.1007/s12274-023-5379-y
https://www.sciopen.com/article/10.1007/s12274-023-5379-y - K. Gulati*. Nano- and Micro-Engineered Biomaterials: Trigger, Therapy and Toxicity Evaluations. Materials Today Advances 2022, 16, 100311 [IF 8.0]. https://doi.org/10.1016/j.mtadv.2022.100311
- A. Jayasree, M.N. Gómez-Cerezo, E. Verron, S. Ivanovski and K. Gulati*. Gallium-doped Dual Micro-Nano Titanium Dental Implants Towards Soft-Tissue Integration and Bactericidal Functions. Materials Today Advances 2022, 16, 100297 [Senior/Last Authorship, *Corresponding Author, IF 8.0]. https://doi.org/10.1016/j.mtadv.2022.100297
- W. Chan, K. Gulati*, and O.A. Peters*. Advancing Nitinol: From Heat Treatment to Surface Functionalization for Nickel-Titanium (NiTi) Instruments in Endodontics. Bioactive Materials 2023, 22, 91–111 [*Corresponding Author, IF 20.3]. https://doi.org/10.1016/j.bioactmat.2022.09.008
- T. Guo, S. Ivanovski and K. Gulati*. Optimizing Titanium Implant Nano-Engineering via Anodization. Materials & Design 2022, 223, 111110 [Senior/Last Authorship, Corresponding Author, IF 7.9]. https://doi.org/10.1016/j.matdes.2022.111110
- T. Guo, S. Ivanovski* and K. Gulati*. Tuning Electrolyte Aging in Titanium Anodization to Fabricate Nano-Engineered Implants. Surface & Coatings Technology 2022, 447, 128819. [Senior/Last Authorship, Corresponding Author, IF 6.1]. https://doi.org/10.1016/j.surfcoat.2022.128819
- D. Chopra, T. Guo, S. Ivanovski* and K. Gulati*. Single-Step Nano-Engineering of Multiple Micro-Rough Metals via Anodization. Nano Research 2023, 16(1): 1320–1329 [Senior/Last Authorship, Corresponding Author, IF 9.0].
https://doi.org/10.1007/s12274-022-4847-8 - A. Jayasree, N.T. Raveendran, T. Guo, S. Ivanovski, and K. Gulati*. Electrochemically Nano-Engineered Titanium: Influence of Dual Micro-Nanotopography of Anisotropic Nanopores on Bioactivity and Antimicrobial Activity. Materials Today Advances 2022, 15, 100256. [Senior/Last Authorship, *Corresponding Author, IF 8.0]. https://doi.org/10.1016/j.mtadv.2022.100256
- K. Gulati*, R.D.O. Martinez, M. Czerwiński and M. Michalska-Domańska*. Understanding the Influence of Electrolyte Aging in Electrochemical Anodization of Titanium. Advances in Colloid and Interface Science 2022, 302, 102615 [*Corresponding Author, IF 19.3]. https://doi.org/10.1016/j.cis.2022.102615
- K. Gulati*. Nano-Engineering Solutions for Dental Implant Applications. Nanomaterials 2022, 12, 272 [Corresponding Author, IF 4.3]. https://doi.org/10.3390/nano12020272
- K. Gulati*, A. Abdal-hay* and S. Ivanovski*. Novel Nano-Engineered Biomaterials for Bone Tissue Engineering. Nanomaterials 2022, 12, 333 [*Corresponding Author, IF 4.3]. https://doi.org/10.3390/nano12030333
2021 (17)
- T. Guo, S. Ivanovski*, and K. Gulati*. Fresh or Aged: Short Time Anodization of Titanium to Understand the Influence of Electrolyte Ageing on Titania Nanopores. Journal of Materials Science & Technology 2022, 119, 245–256 [Senior/Last Authorship, *Corresponding Author, IF 14.3]. https://doi.org/10.1016/j.jmst.2021.11.050
- D. Chopra, A. Jayasree, T. Guo, K. Gulati* and S. Ivanovski*. Advancing Dental Implants: Bioactive and Therapeutic Modifications of Zirconia. Bioactive Materials 2022, 13, 161–178 [*Corresponding Author, IF 20.3]. https://doi.org/10.1016/j.bioactmat.2021.10.010
- D. Chopra, K. Gulati* and S. Ivanovski*. Bed of Nails: Bioinspired Nano-Texturing towards Antibacterial and Bioactivity Functions. Materials Today Advances 2021, 12, 100176 [*Corresponding Author, IF 8.0]. https://doi.org/10.1016/j.mtadv.2021.100176
- A.Q. Alali, A. Abdal-hay, K. Gulati, S. Ivanovski, B. Fournier and R.S.B. Lee. Influence of Bioinspired Lithium-Doped Titanium Implants on Gingival Fibroblast Bioactivity and Biofilm Adhesion. Nanomaterials 2021, 11, 2799. [IF 4.3]. https://doi.org/10.3390/nano11112799
- Y. Zhang#, K. Gulati#, Z. Li, P. Di and Y. Liu. Dental Implant Nano-Engineering: Advances, Limitations and Future Directions. Nanomaterials 2021, 11, 2489. [#Equal First Author Contribution, IF 4.3]. https://doi.org/10.3390/nano11102489
- T. Guo, N.A.K. Oztug, P. Han, S. Ivanovski*, and K. Gulati*. Influence of Sterilization on the Performance of Anodized Nanoporous Titanium Implants. Materials Science & Engineering C. 2021, 130, 112429 [Senior/Last Authorship, *Corresponding Author, IF 8.1]. https://doi.org/10.1016/j.msec.2021.112429
- T. Guo, N.A.K. Oztug, P. Han, S. Ivanovski*, and K. Gulati*. Untwining the topography-chemistry interdependence to optimize the bioactivity of nano-engineered titanium implants. Applied Surface Science 2021, 570, 151083 [Senior/Last Authorship, *Corresponding Author, IF 6.9]. https://doi.org/10.1016/j.apsusc.2021.151083
- K. Gulati, J-C Scimeca, S Ivanovski and E. Verron. Double-Edged Sword: Therapeutic Efficacy vs Toxicity Evaluations of Doped Titanium Implants. Drug Discovery Today 2021, 26 (11), 2734-2742 [IF 7.5]. https://doi.org/10.1016/j.drudis.2021.07.004
- K. Gulati*#, Y. Zhang#, P. Di, Y. Liu*, and S. Ivanovski*. Research to Clinics: Clinical Translation Considerations for Anodized Nano-Engineered Titanium Implants. ACS Biomater. Sci. Eng. 2022, 8, 4077−409 [#Equal First Author Contribution, *Corresponding Author, IF 5.5]. https://doi.org/10.1021/acsbiomaterials.1c00529
- S. Hua, P.M. Bartold, K. Gulati, C. Moran, S. Ivanovski and P. Han. Periodontal and Dental Pulp Cell-Derived Small Extracellular Vesicles: A Review of the Current Status. Nanomaterials 2021, 11, 1858. [IF 4.3]. https://doi.org/10.3390/nano11071858
- D. Chopra, K. Gulati* and S. Ivanovski*. Micro + Nano: Conserving the Gold Standard Micro-Roughness to Nano-Engineer Zirconium Dental Implants. ACS Biomater Sci Eng. 2021, 7, 3069−3074 [Communication Paper, *Corresponding Author, IF 5.5]. https://doi.org/10.1021/acsbiomaterials.1c00356
- D. Chopra, K. Gulati* and S. Ivanovski*. Towards Clinical Translation: Optimized Fabrication of Controlled Nanostructures on Implant-Relevant Curved Zirconium Surfaces. Nanomaterials 2021, 11, 868. [Communication Paper, *Corresponding Author, IF 4.3]. https://doi.org/10.3390/nano11040868
- A. Jayasree, S. Ivanovski* and K. Gulati*. ON or OFF: Triggered Therapies from Anodized Nano-Engineered Titanium Implants. Journal of Controlled Release 2021, 333, 521-535 [Senior/Last Authorship, *Corresponding Author, IF 11.5]. https://doi.org/10.1016/j.jconrel.2021.03.020
- D. Chopra, K. Gulati* and S. Ivanovski*. Understanding and Optimizing the Antibacterial Functions of Anodized Nano-Engineered Titanium Implants. Acta Biomaterialia 2021, 127, 80-101 [*Corresponding Author, IF 9.6]. https://doi.org/10.1016/j.actbio.2021.03.027
- T. Guo, K. Gulati*, H. Arora, P. Han, B. Fournier and S. Ivanovski*. Race to Invade: Understanding Soft Tissue Integration at the Transmucosal Region of Titanium Dental Implants. Dental Materials 2021, 37, 816–831 [*Corresponding Author, IF 6.3]. https://doi.org/10.1016/j.dental.2021.02.005 Featured as the most cited articles published since January 2021.
- T. Guo, N.A.K. Oztug, P. Han, S. Ivanovski*, and K. Gulati*. Old is Gold: Electrolyte Ageing Influences the Topography, Chemistry and Bioactivity of Anodized TiO2 Nanopores. ACS Applied Materials & Interfaces 2021, 13, 7897-7912 [Senior/Last Authorship, *Corresponding Author, IF 8.2]. https://dx.doi.org/10.1021/acsami.0c19569
- T. Guo, K. Gulati*, H. Arora, P. Han, B. Fournier and S. Ivanovski*. Orchestrating Soft Tissue Integration at the Transmucosal Region of Titanium Implants. Acta Biomaterialia 2021, 124, 33-49 [*Corresponding Author, IF 9.6]. https://doi.org/10.1016/j.actbio.2021.01.001
Collaboration
Kyoto University, Kyoto, Japan
Technical University of Munich, Germany
University of Nantes, Nantes, France
UFR d'Odontologie University Paris Diderot, France
Charité – Universitätsmedizin Berlin, Germany
School and Hospital of Stomatology, Peking University, China
RMIT University, VIC
Griffith University, Gold Coast
The University of Sydney
University of New South Wales
QUT, Brisbane
Opportunities
Interested students and postdocs can contact Dr Gulati at k.gulati@uq.edu.au to discuss opportunities.
- GATORs: Gulati’s group for Anodized Therapies for Osseointegration, Regeneration & Stimulation
- Immunoengineering for Regenerative Dentistry
- Biomanufacturing and regenerative dentistry
- Epigenetic nanodiagnostics and therapeutics
- iTEAM
- uQOLA (UQ Oral Microbiomics for Learning and Application)
- Peters’ Regenerative Opportunities in COR3 (PROCOR3)